Annotation Detail

Information
Associated Genes
PTPN11
Associated Variants
PTPN11 p.Ala72Gly (p.A72G) ( ENST00000688597.1, ENST00000635625.1, ENST00000687906.1, ENST00000351677.7, ENST00000392597.5, ENST00000639857.2, ENST00000690210.1 )
PTPN11 p.Ala72Gly (p.A72G) ( ENST00000690210.1, ENST00000688597.1, ENST00000351677.7, ENST00000392597.5, ENST00000635625.1, ENST00000639857.2, ENST00000687906.1 )
Associated Disease
juvenile myelomonocytic leukemia metachondromatosis Noonan syndrome 1 LEOPARD syndrome 1
Source Database
ClinVar
Description
NM_002834.5(PTPN11):c.215C>G (p.Ala72Gly) AND multiple conditions
ClinVar Allele ID
28364
ClinVar RefSeq Alternation Syntax
NM_001330437.2:c.215C>G
ClinVar RefSeq Alternation Syntax
NM_080601.3:c.215C>G
ClinVar RefSeq Alternation Syntax
NM_001374625.1:c.212C>G
ClinVar RefSeq Alternation Syntax
NM_002834.5:c.215C>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2017-05-18
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000515213
ClinVar Disease
LEOPARD syndrome 1
ClinVar Disease
Juvenile myelomonocytic leukemia
ClinVar Disease
Noonan syndrome 1
ClinVar Disease
Metachondromatosis
Observed Origin Sample
unknown
Drugs