Annotation Detail

Information
Associated Genes
SMAD4
Associated Variants
SMAD4 p.Arg361Cys (p.R361C) ( ENST00000588745.5, ENST00000398417.6, ENST00000342988.8, ENST00000590061.2, ENST00000593223.2, ENST00000714261.1, ENST00000714264.1, ENST00000714266.1, ENST00000588860.6, ENST00000589076.6, ENST00000589941.2, ENST00000714268.1, ENST00000714269.1, ENST00000714270.1, ENST00000714272.1 )
SMAD4 p.Arg361Cys (p.R361C) ( ENST00000714266.1, ENST00000714264.1, ENST00000714261.1, ENST00000593223.2, ENST00000590061.2, ENST00000589941.2, ENST00000589076.6, ENST00000588860.6, ENST00000588745.5, ENST00000398417.6, ENST00000342988.8, ENST00000714270.1, ENST00000714272.1, ENST00000714269.1, ENST00000714268.1 )
Associated Disease
Carcinoma of esophagus
Source Database
ClinVar
Description
NM_005359.6(SMAD4):c.1081C>T (p.Arg361Cys) AND Carcinoma of esophagus
ClinVar Allele ID
23582
ClinVar RefSeq Alternation Syntax
NM_005359.6:c.1081C>T
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2016-05-31
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000435832
ClinVar Disease
Carcinoma of esophagus
Observed Origin Sample
somatic
Drugs