Annotation Detail

Information
Associated Genes
CYP21A2 TNXB LOC106780800
Associated Variants
CYP21A2 p.Leu308PhefsTer6 (p.L308Ffs*6) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Leu308PhefsTer6 (p.L308Ffs*6) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Val282Leu (p.V282L) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Gln319Ter (p.Q319*) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Arg357Trp (p.R357W) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Val282Leu (p.V282L) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Gln319Ter (p.Q319*) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Arg357Trp (p.R357W) ( ENST00000435122.3, ENST00000644719.2 )
Associated Disease
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Source Database
ClinVar
Description
NM_000500.7(CYP21A2):c.[844G>T;920_921insT;955C>T;1069C>T] AND Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
ClinVar Allele ID
27190
ClinVar Allele ID
27191
ClinVar Allele ID
76519
ClinVar Allele ID
27208
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.664C>T
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.518dup
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.979C>T
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.833dup
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.844G>T
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.550C>T
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.754G>T
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.439G>T
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.923dup
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.439G>T
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.664C>T
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.865C>T
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.550C>T
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.955C>T
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.1069C>T
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.518dup
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2003-08-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000417198
ClinVar Disease
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Observed Origin Sample
germline
Pubmed
7629224
Pubmed
12915679
Pubmed
11093272
Drugs