Annotation Detail

Information
Associated Genes
ABCA4
Associated Variants
ABCA4 p.Val2050Leu (p.V2050L) ( ENST00000370225.4 )
ABCA4 p.Ala1794Asp (p.A1794D) ( ENST00000370225.4 )
ABCA4 p.Val2050Leu (p.V2050L) ( ENST00000370225.4 )
ABCA4 p.Ala1794Asp (p.A1794D) ( ENST00000370225.4 )
Associated Disease
Severe early-childhood-onset retinal dystrophy
Source Database
ClinVar
Description
NM_000350.2(ABCA4):c.[5381C>A;6148G>C] AND Severe early-childhood-onset retinal dystrophy
ClinVar Allele ID
22923
ClinVar Allele ID
105260
ClinVar RefSeq Alternation Syntax
NM_000350.3:c.5381C>A
ClinVar RefSeq Alternation Syntax
NM_000350.3:c.6148G>C
ClinVar RefSeq Alternation Syntax
NM_001425324.1:c.5926G>C
ClinVar RefSeq Alternation Syntax
NM_001425324.1:c.5159C>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2016-01-01
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000408516
ClinVar Disease
Severe early-childhood-onset retinal dystrophy
Observed Origin Sample
germline
Drugs