Annotation Detail

Information
Associated Genes
SRD5A2
Associated Variants
SRD5A2 p.Glu227Lys (p.E227K) ( ENST00000622030.2 )
SRD5A2 p.Arg227Gln (p.R227Q) ( ENST00000622030.2 )
Associated Disease
3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency
Source Database
ClinVar
Description
NM_000348.4(SRD5A2):c.680G>A (p.Arg227Gln) AND 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency
ClinVar Allele ID
18390
ClinVar RefSeq Alternation Syntax
NM_000348.4:c.680G>A
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2024-01-30
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000288398
ClinVar Disease
3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency
Observed Origin Sample
germline
Observed Origin Sample
inherited
Observed Origin Sample
somatic
Observed Origin Sample
unknown
Drugs