Annotation Detail

Information
Associated Genes
GJB2
Associated Variants
GJB2 p.Tyr136Ter (p.Y136*) ( ENST00000382848.5, ENST00000382844.2 )
GJB2 p.Gly45Glu (p.G45E) ( ENST00000382844.2, ENST00000382848.5 )
GJB2 p.Tyr136Ter (p.Y136*) ( ENST00000382848.5, ENST00000382844.2 )
GJB2 p.Gly45Glu (p.G45E) ( ENST00000382844.2, ENST00000382848.5 )
Associated Disease
Autosomal recessive nonsyndromic hearing loss 1A
Source Database
ClinVar
Description
NM_004004.5(GJB2):c.[134G>A;408C>A] AND Autosomal recessive nonsyndromic hearing loss 1A
ClinVar Allele ID
186856
ClinVar Allele ID
32072
ClinVar RefSeq Alternation Syntax
NM_004004.6:c.134G>A
ClinVar RefSeq Alternation Syntax
NM_004004.6:c.408C>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2017-05-09
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000258130
ClinVar Disease
Autosomal recessive nonsyndromic hearing loss 1A
Observed Origin Sample
germline
Pubmed
24785414
Pubmed
20497192
Pubmed
15633193
Pubmed
12560944
Drugs