Annotation Detail

Information
Associated Genes
ACTA2
Associated Variants
ACTA2 p.Arg149Cys (p.R149C) ( ENST00000713597.1, ENST00000224784.10, ENST00000713600.1, ENST00000713601.1, ENST00000415557.2, ENST00000713598.1, ENST00000371927.7, ENST00000713602.1, ENST00000713599.1, ENST00000458159.6 )
ACTA2 p.Arg149Cys (p.R149C) ( ENST00000224784.10, ENST00000415557.2, ENST00000458159.6, ENST00000713597.1, ENST00000713598.1, ENST00000713599.1, ENST00000713600.1, ENST00000713601.1, ENST00000713602.1, ENST00000371927.7 )
Associated Disease
Familial thoracic aortic aneurysm and aortic dissection
Source Database
ClinVar
Description
NM_001613.4(ACTA2):c.445C>T (p.Arg149Cys) AND Familial thoracic aortic aneurysm and aortic dissection
ClinVar Allele ID
33315
ClinVar RefSeq Alternation Syntax
NM_001406471.1:c.445C>T
ClinVar RefSeq Alternation Syntax
NM_001613.4:c.445C>T
ClinVar RefSeq Alternation Syntax
NM_001320855.2:c.445C>T
ClinVar RefSeq Alternation Syntax
NM_001406464.1:c.445C>T
ClinVar RefSeq Alternation Syntax
NM_001406466.1:c.334C>T
ClinVar RefSeq Alternation Syntax
NM_001406469.1:c.316C>T
ClinVar RefSeq Alternation Syntax
NM_001406468.1:c.316C>T
ClinVar RefSeq Alternation Syntax
NM_001406467.1:c.316C>T
ClinVar RefSeq Alternation Syntax
NM_001406462.1:c.445C>T
ClinVar RefSeq Alternation Syntax
NM_001406463.1:c.445C>T
ClinVar RefSeq Alternation Syntax
NM_001141945.3:c.445C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-11-07
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000246692
ClinVar Disease
Familial thoracic aortic aneurysm and aortic dissection
Observed Origin Sample
germline
Drugs