Annotation Detail

Information
Associated Genes
PCSK9
Associated Variants
PCSK9 p.Arg46Leu (p.R46L) ( ENST00000302118.5, ENST00000713786.1, ENST00000710286.1 )
PCSK9 p.Arg46Leu (p.R46L) ( ENST00000302118.5, ENST00000710286.1, ENST00000713786.1 )
Associated Disease
Hypercholesterolemia, autosomal dominant, 3
Source Database
ClinVar
Description
NM_174936.4(PCSK9):c.137G>T (p.Arg46Leu) AND Hypercholesterolemia, autosomal dominant, 3
ClinVar Allele ID
17917
ClinVar RefSeq Alternation Syntax
NM_174936.4:c.137G>T
Clinical Significance Description
Benign/Likely benign
Clinical Significance Last Update
2024-01-31
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000203182
ClinVar Disease
Hypercholesterolemia, autosomal dominant, 3
Observed Origin Sample
germline
Observed Origin Sample
unknown
Drugs