Annotation Detail

Information
Associated Genes
FBXL4
Associated Variants
FBXL4 p.Arg22Ter (p.R22*) ( ENST00000229971.2, ENST00000369244.7 )
FBXL4 p.Arg22Ter (p.R22*) ( ENST00000229971.2, ENST00000369244.7 )
Associated Disease
mitochondrial DNA depletion syndrome 13
Source Database
ClinVar
Description
NM_001278716.2(FBXL4):c.64C>T (p.Arg22Ter) AND Mitochondrial DNA depletion syndrome 13
ClinVar Allele ID
205749
ClinVar RefSeq Alternation Syntax
NM_001278716.2:c.64C>T
ClinVar RefSeq Alternation Syntax
NR_103836.2:n.395C>T
ClinVar RefSeq Alternation Syntax
NR_103837.2:n.395C>T
ClinVar RefSeq Alternation Syntax
NM_012160.5:c.64C>T
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2022-03-23
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000191084
ClinVar Disease
Mitochondrial DNA depletion syndrome 13
Observed Origin Sample
germline
Observed Origin Sample
inherited
Observed Origin Sample
maternal
Observed Origin Sample
unknown
Drugs