Annotation Detail

Information
Associated Genes
OPA1
Associated Variants
OPA1 p.Thr486LysfsTer18 (p.T486Kfs*18) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
OPA1 p.Thr486LysfsTer18 (p.T486Kfs*18) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
Associated Disease
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
Source Database
ClinVar
Description
NM_130837.3(OPA1):c.1511del (p.Thr504fs) AND Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
ClinVar Allele ID
198617
ClinVar RefSeq Alternation Syntax
NM_130834.3:c.1400del
ClinVar RefSeq Alternation Syntax
NM_130836.3:c.1457del
ClinVar RefSeq Alternation Syntax
NM_001354663.2:c.977del
ClinVar RefSeq Alternation Syntax
NM_130835.3:c.1403del
ClinVar RefSeq Alternation Syntax
NM_001354664.2:c.974del
ClinVar RefSeq Alternation Syntax
NM_130831.3:c.1238del
ClinVar RefSeq Alternation Syntax
NM_015560.3:c.1346del
ClinVar RefSeq Alternation Syntax
NM_130837.3:c.1511del
ClinVar RefSeq Alternation Syntax
NM_130832.3:c.1292del
ClinVar RefSeq Alternation Syntax
NM_130833.3:c.1349del
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2012-04-18
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000184014
ClinVar Disease
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
Observed Origin Sample
unknown
Drugs