Annotation Detail

Information
Associated Genes
AIRE
Associated Variants
AIRE p.Arg257Ter (p.R257*) ( ENST00000291582.6 )
AIRE p.Arg257Ter (p.R257*) ( ENST00000291582.6 )
Associated Disease
Polyglandular autoimmune syndrome, type 1
Source Database
ClinVar
Description
NM_000383.4(AIRE):c.769C>T (p.Arg257Ter) AND Polyglandular autoimmune syndrome, type 1
ClinVar Allele ID
18346
ClinVar RefSeq Alternation Syntax
NM_000383.4:c.769C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2024-01-31
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000179294
ClinVar Disease
Polyglandular autoimmune syndrome, type 1
Observed Origin Sample
germline
Observed Origin Sample
unknown
Observed Origin Sample
maternal
Pubmed
9398839
Pubmed
9921903
Pubmed
12050215
Pubmed
6031738
Pubmed
9398840
Pubmed
19807739
Pubmed
16965330
Pubmed
17539912
Drugs