Annotation Detail

Information
Associated Genes
DHCR7
Associated Variants
DHCR7 p.? (p.?) ( ENST00000407721.6, ENST00000527316.6, ENST00000683287.1, ENST00000355527.8, ENST00000526780.6, ENST00000682880.1, ENST00000682708.1, ENST00000683714.1, ENST00000685320.1 )
DHCR7 p.? (p.?) ( ENST00000355527.8, ENST00000407721.6, ENST00000526780.6, ENST00000527316.6, ENST00000682708.1, ENST00000682880.1, ENST00000683287.1, ENST00000683714.1, ENST00000685320.1 )
Associated Disease
Smith-Lemli-Opitz syndrome
Source Database
ClinVar
Description
NM_001360.3(DHCR7):c.1A>G (p.Met1Val) AND Smith-Lemli-Opitz syndrome
ClinVar Allele ID
21833
ClinVar RefSeq Alternation Syntax
NM_001163817.2:c.1A>G
ClinVar RefSeq Alternation Syntax
NM_001360.3:c.1A>G
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2024-03-14
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000169384
ClinVar Disease
Smith-Lemli-Opitz syndrome
Observed Origin Sample
germline
Observed Origin Sample
unknown
Pubmed
9634533
Pubmed
15952211
Drugs