Annotation Detail

Information
Associated Genes
MTHFR
Associated Variants
MTHFR p.Tyr547Asp (p.Y547D) ( ENST00000376585.6, ENST00000376583.7, ENST00000423400.7, ENST00000641820.1, ENST00000376590.9, ENST00000641407.1, ENST00000376592.6 )
MTHFR p.Tyr547Asp (p.Y547D) ( ENST00000376583.7, ENST00000376585.6, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 )
Associated Disease
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
Source Database
ClinVar
Description
NM_005957.5(MTHFR):c.1516T>G (p.Tyr506Asp) AND Homocystinuria due to methylene tetrahydrofolate reductase deficiency
ClinVar Allele ID
185769
ClinVar RefSeq Alternation Syntax
NM_001330358.2:c.1639T>G
ClinVar RefSeq Alternation Syntax
NM_005957.5:c.1516T>G
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2021-11-05
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000167614
ClinVar Disease
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
Observed Origin Sample
germline
Drugs