Annotation Detail

Information
Associated Genes
MRE11
Associated Variants
MRE11 p.Leu274HisfsTer16 (p.L274Hfs*16) ( ENST00000323929.8, ENST00000323977.7, ENST00000393241.8, ENST00000407439.7 )
MRE11 p.Leu274HisfsTer16 (p.L274Hfs*16) ( ENST00000323929.8, ENST00000323977.7, ENST00000393241.8, ENST00000407439.7 )
Associated Disease
Hereditary cancer-predisposing syndrome
Source Database
ClinVar
Description
NM_005591.4(MRE11):c.821_823delinsA (p.Leu274fs) AND Hereditary cancer-predisposing syndrome
ClinVar Allele ID
183555
ClinVar RefSeq Alternation Syntax
NM_001330347.2:c.821_823delinsA
ClinVar RefSeq Alternation Syntax
NM_005591.4:c.821_823delinsA
ClinVar RefSeq Alternation Syntax
NM_005590.4:c.821_823delinsA
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-09-26
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000164635
ClinVar Disease
Hereditary cancer-predisposing syndrome
Observed Origin Sample
germline
Drugs