Annotation Detail

Information
Associated Genes
PTPN11
Associated Variants
PTPN11 p.Thr472Met (p.T472M) ( ENST00000351677.7, ENST00000635625.1, ENST00000639857.2, ENST00000687906.1, ENST00000688597.1, ENST00000690210.1 )
PTPN11 p.Thr472Met (p.T472M) ( ENST00000351677.7, ENST00000635625.1, ENST00000639857.2, ENST00000687906.1, ENST00000688597.1, ENST00000690210.1 )
Associated Disease
Noonan syndrome
Source Database
ClinVar
Description
NM_002834.5(PTPN11):c.1403C>T (p.Thr468Met) AND Noonan syndrome
ClinVar Allele ID
28370
ClinVar RefSeq Alternation Syntax
NM_001374625.1:c.1400C>T
ClinVar RefSeq Alternation Syntax
NM_002834.5:c.1403C>T
ClinVar RefSeq Alternation Syntax
NM_001330437.2:c.1415C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-03-05
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000157014
ClinVar Disease
Noonan syndrome
Observed Origin Sample
germline
Drugs