Annotation Detail

Information
Associated Genes
CHEK2
Associated Variants
CHEK2 c.721+3A>T ( ENST00000348295.7, ENST00000382580.6, ENST00000402731.6, ENST00000403642.5, ENST00000404276.6, ENST00000405598.5, ENST00000425190.7, ENST00000649563.1, ENST00000650281.1 )
CHEK2 c.721+3A>T ( ENST00000348295.7, ENST00000382580.6, ENST00000402731.6, ENST00000403642.5, ENST00000404276.6, ENST00000405598.5, ENST00000425190.7, ENST00000649563.1, ENST00000650281.1 )
Associated Disease
Hereditary cancer-predisposing syndrome
Source Database
ClinVar
Description
NM_007194.4(CHEK2):c.592+3A>T AND Hereditary cancer-predisposing syndrome
ClinVar Allele ID
152670
ClinVar RefSeq Alternation Syntax
NM_007194.4:c.592+3A>T
ClinVar RefSeq Alternation Syntax
NM_145862.2:c.592+3A>T
ClinVar RefSeq Alternation Syntax
NM_001005735.2:c.721+3A>T
ClinVar RefSeq Alternation Syntax
NM_001257387.2:c.-186+3A>T
ClinVar RefSeq Alternation Syntax
NM_001349956.2:c.445-51A>T
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2023-08-14
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000132447
ClinVar Disease
Hereditary cancer-predisposing syndrome
Observed Origin Sample
germline
Drugs