Annotation Detail

Information
Associated Genes
GAA
Associated Variants
GAA p.Asp645Glu (p.D645E) ( ENST00000714055.1, ENST00000302262.8, ENST00000714058.1, ENST00000714062.1, ENST00000390015.7, ENST00000570803.6, ENST00000577106.6, ENST00000714054.1, ENST00000714057.1 )
GAA p.Asp645Glu (p.D645E) ( ENST00000302262.8, ENST00000390015.7, ENST00000570803.6, ENST00000577106.6, ENST00000714054.1, ENST00000714055.1, ENST00000714057.1, ENST00000714058.1, ENST00000714062.1 )
Associated Disease
Glycogen storage disease, type II
Source Database
ClinVar
Description
NM_000152.5(GAA):c.1935C>A (p.Asp645Glu) AND Glycogen storage disease, type II
ClinVar Allele ID
19068
ClinVar RefSeq Alternation Syntax
NM_001079804.3:c.1935C>A
ClinVar RefSeq Alternation Syntax
NM_001079803.3:c.1935C>A
ClinVar RefSeq Alternation Syntax
NM_000152.5:c.1935C>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2021-09-07
Clinical Significance Review Status
reviewed by expert panel
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000055768
ClinVar Disease
Glycogen storage disease, type II
Observed Origin Sample
germline
Observed Origin Sample
inherited
Observed Origin Sample
maternal
Observed Origin Sample
unknown
Drugs