Annotation Detail

Information
Associated Genes
AIRE
Associated Variants
AIRE p.Ter546Cysext*? (p.*546Cext*?) ( ENST00000291582.6 )
AIRE p.Ter546Cysext*? (p.*546Cext*?) ( ENST00000291582.6 )
Associated Disease
Polyglandular autoimmune syndrome, type 1
Source Database
ClinVar
Description
NM_000383.4(AIRE):c.1638A>T (p.Ter546Cys) AND Polyglandular autoimmune syndrome, type 1
ClinVar Allele ID
70861
ClinVar RefSeq Alternation Syntax
NM_000383.4:c.1638A>T
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2023-09-04
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000049633
ClinVar Disease
Polyglandular autoimmune syndrome, type 1
Observed Origin Sample
germline
Observed Origin Sample
not provided
Observed Origin Sample
unknown
Drugs