Annotation Detail

Information
Associated Genes
BRAF
Associated Variants
BRAF p.Thr241Lys (p.T241K) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
BRAF p.Thr241Lys (p.T241K) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Associated Disease
Noonan syndrome
Source Database
ClinVar
Description
NM_004333.6(BRAF):c.722C>A (p.Thr241Lys) AND Noonan syndrome
ClinVar Allele ID
53996
ClinVar RefSeq Alternation Syntax
NM_001378472.1:c.566C>A
ClinVar RefSeq Alternation Syntax
NM_001378468.1:c.722C>A
ClinVar RefSeq Alternation Syntax
NM_004333.6:c.722C>A
ClinVar RefSeq Alternation Syntax
NM_001378474.1:c.722C>A
ClinVar RefSeq Alternation Syntax
NM_001374258.1:c.722C>A
ClinVar RefSeq Alternation Syntax
NM_001378475.1:c.458C>A
ClinVar RefSeq Alternation Syntax
NM_001378467.1:c.731C>A
ClinVar RefSeq Alternation Syntax
NM_001378473.1:c.566C>A
ClinVar RefSeq Alternation Syntax
NM_001378469.1:c.722C>A
ClinVar RefSeq Alternation Syntax
NM_001354609.2:c.722C>A
ClinVar RefSeq Alternation Syntax
NM_001378471.1:c.722C>A
ClinVar RefSeq Alternation Syntax
NM_001378470.1:c.620C>A
ClinVar RefSeq Alternation Syntax
NM_001374244.1:c.722C>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2013-06-07
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000037953
ClinVar Disease
Noonan syndrome
Observed Origin Sample
germline
Drugs