Annotation Detail

Information
Associated Genes
PTPN11
Associated Variants
PTPN11 p.Ala465Ser (p.A465S) ( ENST00000688597.1, ENST00000690210.1, ENST00000639857.2, ENST00000635625.1, ENST00000687906.1, ENST00000351677.7 )
PTPN11 p.Ala465Ser (p.A465S) ( ENST00000351677.7, ENST00000635625.1, ENST00000639857.2, ENST00000687906.1, ENST00000688597.1, ENST00000690210.1 )
Associated Disease
Noonan syndrome with multiple lentigines
Source Database
ClinVar
Description
NM_002834.5(PTPN11):c.1381G>T (p.Ala461Ser) AND Noonan syndrome with multiple lentigines
ClinVar Allele ID
49016
ClinVar RefSeq Alternation Syntax
NM_001330437.2:c.1393G>T
ClinVar RefSeq Alternation Syntax
NM_002834.5:c.1381G>T
ClinVar RefSeq Alternation Syntax
NM_001374625.1:c.1378G>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2009-07-16
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000037612
ClinVar Disease
Noonan syndrome with multiple lentigines
Observed Origin Sample
germline
Drugs