Annotation Detail

Information
Associated Genes
TP53
Associated Variants
TP53 p.Leu26GlnfsTer4 (p.L26Qfs*4) ( ENST00000269305.9, ENST00000610538.4, ENST00000714357.1, ENST00000610292.4, ENST00000604348.6, ENST00000359597.8, ENST00000714409.1, ENST00000714359.1, ENST00000413465.6, ENST00000714356.1, ENST00000420246.6, ENST00000622645.4, ENST00000576024.2, ENST00000714408.1, ENST00000455263.6, ENST00000620739.4, ENST00000619485.4, ENST00000445888.6 )
TP53 p.Leu26GlnfsTer4 (p.L26Qfs*4) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
Associated Disease
Li-Fraumeni syndrome
Source Database
ClinVar
Description
NM_000546.6(TP53):c.77_80delinsAAGAACGT (p.Leu26fs) AND Li-Fraumeni syndrome
ClinVar Allele ID
52762
ClinVar RefSeq Alternation Syntax
NM_001126118.2:c.-41_-38delinsAAGAACGT
ClinVar RefSeq Alternation Syntax
NM_001276696.3:c.-41_-38delinsAAGAACGT
ClinVar RefSeq Alternation Syntax
NM_001276695.3:c.-41_-38delinsAAGAACGT
ClinVar RefSeq Alternation Syntax
NM_000546.6:c.77_80delinsAAGAACGT
ClinVar RefSeq Alternation Syntax
NM_001276761.3:c.-41_-38delinsAAGAACGT
ClinVar RefSeq Alternation Syntax
NM_001126112.3:c.77_80delinsAAGAACGT
ClinVar RefSeq Alternation Syntax
NM_001126113.3:c.77_80delinsAAGAACGT
ClinVar RefSeq Alternation Syntax
NM_001126114.3:c.77_80delinsAAGAACGT
ClinVar RefSeq Alternation Syntax
NM_001276760.3:c.-41_-38delinsAAGAACGT
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2009-02-05
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000036535
ClinVar Disease
Li-Fraumeni syndrome
Observed Origin Sample
germline
Drugs