Annotation Detail

Information
Associated Genes
PTPN11
Associated Variants
PTPN11 p.Glu76Lys (p.E76K) ( ENST00000392597.5, ENST00000351677.7, ENST00000635625.1, ENST00000639857.2, ENST00000687906.1, ENST00000688597.1, ENST00000690210.1 )
PTPN11 p.Glu76Lys (p.E76K) ( ENST00000351677.7, ENST00000392597.5, ENST00000635625.1, ENST00000639857.2, ENST00000687906.1, ENST00000688597.1, ENST00000690210.1 )
Associated Disease
RASopathy
Source Database
ClinVar
Description
NM_002834.5(PTPN11):c.226G>A (p.Glu76Lys) AND RASopathy
ClinVar Allele ID
28375
ClinVar RefSeq Alternation Syntax
NM_001330437.2:c.226G>A
ClinVar RefSeq Alternation Syntax
NM_001374625.1:c.223G>A
ClinVar RefSeq Alternation Syntax
NM_080601.3:c.226G>A
ClinVar RefSeq Alternation Syntax
NM_002834.5:c.226G>A
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2020-03-04
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000033476
ClinVar Disease
RASopathy
Observed Origin Sample
germline
Observed Origin Sample
unknown
Drugs