Annotation Detail

Information
Associated Genes
PIK3CA
Associated Variants
PIK3CA p.Cys378Tyr (p.C378Y) ( ENST00000263967.4, ENST00000643187.1 )
PIK3CA p.Cys378Tyr (p.C378Y) ( ENST00000263967.4, ENST00000643187.1 )
Associated Disease
Megalencephaly-capillary malformation-polymicrogyria syndrome
Source Database
ClinVar
Description
NM_006218.4(PIK3CA):c.1133G>A (p.Cys378Tyr) AND Megalencephaly-capillary malformation-polymicrogyria syndrome
ClinVar Allele ID
48303
ClinVar RefSeq Alternation Syntax
NM_006218.4:c.1133G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-02-23
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000032908
ClinVar Disease
Megalencephaly-capillary malformation-polymicrogyria syndrome
Observed Origin Sample
somatic
Observed Origin Sample
unknown
Pubmed
22729224
Drugs