Annotation Detail

Information
Associated Genes
PIK3CA
Associated Variants
PIK3CA p.Gly914Arg (p.G914R) ( ENST00000263967.4, ENST00000643187.1 )
PIK3CA p.Gly914Arg (p.G914R) ( ENST00000263967.4, ENST00000643187.1 )
Associated Disease
Megalencephaly-capillary malformation-polymicrogyria syndrome
Source Database
ClinVar
Description
NM_006218.4(PIK3CA):c.2740G>A (p.Gly914Arg) AND Megalencephaly-capillary malformation-polymicrogyria syndrome
ClinVar Allele ID
48302
ClinVar RefSeq Alternation Syntax
NM_006218.4:c.2740G>A
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2017-09-01
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000032907
ClinVar Disease
Megalencephaly-capillary malformation-polymicrogyria syndrome
Observed Origin Sample
germline
Observed Origin Sample
de novo
Observed Origin Sample
somatic
Pubmed
22228622
Pubmed
22729224
Drugs