Annotation Detail

Information
Associated Genes
HRC TRPM4
Associated Variants
TRPM4 p.Ala432Thr (p.A432T) ( ENST00000252826.10, ENST00000427978.6 )
TRPM4 p.Ala432Thr (p.A432T) ( ENST00000252826.10, ENST00000427978.6 )
Associated Disease
progressive familial heart block type IB
Source Database
ClinVar
Description
NM_017636.4(TRPM4):c.1294G>A (p.Ala432Thr) AND Progressive familial heart block type IB
ClinVar Allele ID
44160
ClinVar RefSeq Alternation Syntax
NM_017636.4:c.1294G>A
ClinVar RefSeq Alternation Syntax
NM_001195227.2:c.1294G>A
ClinVar RefSeq Alternation Syntax
NM_001321281.2:c.949G>A
ClinVar RefSeq Alternation Syntax
NM_001321282.2:c.-260G>A
ClinVar RefSeq Alternation Syntax
NM_001321283.2:c.772G>A
ClinVar RefSeq Alternation Syntax
NM_001321285.2:c.232G>A
Clinical Significance Description
Conflicting interpretations of pathogenicity
Clinical Significance Last Update
2024-01-30
Clinical Significance Review Status
criteria provided, conflicting interpretations
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000029159
ClinVar Disease
Progressive familial heart block type IB
Observed Origin Sample
germline
Pubmed
619595
Pubmed
20562447
Pubmed
30021168
Pubmed
21887725
Drugs