Annotation Detail

Information
Associated Genes
OPA1
Associated Variants
OPA1 p.Gly476Val (p.G476V) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
OPA1 p.Gly476Val (p.G476V) ( ENST00000361150.6, ENST00000361510.8, ENST00000361715.6, ENST00000361828.7, ENST00000361908.8, ENST00000392436.7, ENST00000392437.6, ENST00000643329.1, ENST00000645553.1, ENST00000646793.1 )
Associated Disease
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
Source Database
ClinVar
Description
NM_130837.3(OPA1):c.1481G>T (p.Gly494Val) AND Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
ClinVar Allele ID
39419
ClinVar RefSeq Alternation Syntax
NM_130834.3:c.1370G>T
ClinVar RefSeq Alternation Syntax
NM_130837.3:c.1481G>T
ClinVar RefSeq Alternation Syntax
NM_130833.3:c.1319G>T
ClinVar RefSeq Alternation Syntax
NM_130836.3:c.1427G>T
ClinVar RefSeq Alternation Syntax
NM_001354664.2:c.944G>T
ClinVar RefSeq Alternation Syntax
NM_130835.3:c.1373G>T
ClinVar RefSeq Alternation Syntax
NM_001354663.2:c.947G>T
ClinVar RefSeq Alternation Syntax
NM_015560.3:c.1316G>T
ClinVar RefSeq Alternation Syntax
NM_130831.3:c.1208G>T
ClinVar RefSeq Alternation Syntax
NM_130832.3:c.1262G>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2008-02-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000023416
ClinVar Disease
Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy
Observed Origin Sample
germline
Pubmed
18158317
Drugs