Annotation Detail

Information
Associated Genes
ARSA
Associated Variants
ARSA p.Asp257His (p.D257H) ( ENST00000216124.10, ENST00000356098.9, ENST00000395619.3, ENST00000395621.7, ENST00000453344.6 )
ARSA p.Asp257His (p.D257H) ( ENST00000216124.10, ENST00000356098.9, ENST00000395619.3, ENST00000395621.7, ENST00000453344.6 )
Associated Disease
metachromatic leukodystrophy
Source Database
ClinVar
Description
NM_000487.6(ARSA):c.769G>C (p.Asp257His) AND Metachromatic leukodystrophy
ClinVar Allele ID
34039
ClinVar RefSeq Alternation Syntax
NM_001085425.3:c.769G>C
ClinVar RefSeq Alternation Syntax
NM_001362782.2:c.511G>C
ClinVar RefSeq Alternation Syntax
NM_001085427.3:c.769G>C
ClinVar RefSeq Alternation Syntax
NM_000487.6:c.769G>C
ClinVar RefSeq Alternation Syntax
NM_001085426.3:c.769G>C
ClinVar RefSeq Alternation Syntax
NM_001085428.3:c.511G>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2024-01-26
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000020322
ClinVar Disease
Metachromatic leukodystrophy
Observed Origin Sample
germline
Observed Origin Sample
not applicable
Observed Origin Sample
unknown
Drugs