Annotation Detail

Information
Associated Genes
CFH
Associated Variants
ENSG00000289697 p.Arg127Leu (p.R127L), CFH p.Arg127Leu (p.R127L) ( ENST00000695981.1, ENST00000359637.3, ENST00000695984.1, ENST00000695970.1, ENST00000367429.9, ENST00000695976.1, ENST00000695969.1, ENST00000695974.1, ENST00000695971.1, ENST00000695979.1, ENST00000695968.1, ENST00000696030.1, ENST00000696028.1, ENST00000630130.2, ENST00000696023.1, ENST00000696029.1, ENST00000695978.1, ENST00000695987.1, ENST00000696027.1 )
ENSG00000289697 p.Arg127Leu (p.R127L), CFH p.Arg127Leu (p.R127L) ( ENST00000359637.3, ENST00000367429.9, ENST00000630130.2, ENST00000695968.1, ENST00000695969.1, ENST00000695970.1, ENST00000695971.1, ENST00000695974.1, ENST00000695976.1, ENST00000695978.1, ENST00000695979.1, ENST00000695981.1, ENST00000695984.1, ENST00000695987.1, ENST00000696023.1, ENST00000696027.1, ENST00000696028.1, ENST00000696029.1, ENST00000696030.1 )
Associated Disease
Factor H deficiency
Source Database
ClinVar
Description
NM_000186.4(CFH):c.380G>T (p.Arg127Leu) AND Factor H deficiency
ClinVar Allele ID
31593
ClinVar RefSeq Alternation Syntax
NM_000186.4:c.380G>T
ClinVar RefSeq Alternation Syntax
NM_001014975.3:c.380G>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2004-03-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000018021
ClinVar Disease
Factor H deficiency
Observed Origin Sample
germline
Pubmed
14978182
Drugs