Annotation Detail

Information
Associated Genes
FGFR3
Associated Variants
FGFR3 p.Asn542Lys (p.N542K) ( ENST00000340107.9, ENST00000481110.7, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8 )
FGFR3 p.Asn542Lys (p.N542K) ( ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8, ENST00000481110.7 )
Associated Disease
hypochondroplasia
Source Database
ClinVar
Description
NM_000142.5(FGFR3):c.1620C>A (p.Asn540Lys) AND Hypochondroplasia
ClinVar Allele ID
31376
ClinVar RefSeq Alternation Syntax
NM_000142.5:c.1620C>A
ClinVar RefSeq Alternation Syntax
NM_001354809.2:c.1623C>A
ClinVar RefSeq Alternation Syntax
NM_001163213.2:c.1626C>A
ClinVar RefSeq Alternation Syntax
NM_001354810.2:c.1623C>A
ClinVar RefSeq Alternation Syntax
NR_148971.2:n.2046C>A
ClinVar RefSeq Alternation Syntax
NM_022965.4:c.1284C>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2024-01-22
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000017740
ClinVar Disease
Hypochondroplasia
Observed Origin Sample
germline
Observed Origin Sample
de novo
Observed Origin Sample
unknown
Pubmed
9672519
Pubmed
10360393
Pubmed
9450868
Pubmed
10360392
Pubmed
7670477
Pubmed
4697848
Pubmed
8589686
Pubmed
9842995
Drugs