Annotation Detail

Information
Associated Genes
FGFR3
Associated Variants
FGFR3 p.Arg248Cys (p.R248C) ( ENST00000481110.7, ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8 )
FGFR3 p.Arg248Cys (p.R248C) ( ENST00000340107.9, ENST00000352904.6, ENST00000412135.7, ENST00000440486.8, ENST00000481110.7 )
Associated Disease
Thanatophoric dysplasia type 1
Source Database
ClinVar
Description
NM_000142.5(FGFR3):c.742C>T (p.Arg248Cys) AND Thanatophoric dysplasia type 1
ClinVar Allele ID
31371
ClinVar RefSeq Alternation Syntax
NR_148971.2:n.1017C>T
ClinVar RefSeq Alternation Syntax
NM_001163213.2:c.742C>T
ClinVar RefSeq Alternation Syntax
NM_001354809.2:c.742C>T
ClinVar RefSeq Alternation Syntax
NM_000142.5:c.742C>T
ClinVar RefSeq Alternation Syntax
NM_001354810.2:c.742C>T
ClinVar RefSeq Alternation Syntax
NM_022965.4:c.742C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-09-21
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000017731
ClinVar Disease
Thanatophoric dysplasia type 1
Observed Origin Sample
germline
Observed Origin Sample
de novo
Observed Origin Sample
maternal
Observed Origin Sample
unknown
Pubmed
12833394
Pubmed
10073901
Pubmed
7773297
Pubmed
15772091
Pubmed
16841094
Pubmed
18642369
Pubmed
9677066
Pubmed
11529856
Pubmed
8858131
Drugs