Annotation Detail

Information
Associated Genes
IDH2
Associated Variants
IDH2 p.Arg140Gln (p.R140Q) ( ENST00000540499.2, ENST00000330062.8, ENST00000559482.5 )
IDH2 p.Arg140Gln (p.R140Q) ( ENST00000330062.8, ENST00000540499.2, ENST00000559482.5 )
Associated Disease
D-2-hydroxyglutaric aciduria 2
Source Database
ClinVar
Description
NM_002168.4(IDH2):c.419G>A (p.Arg140Gln) AND D-2-hydroxyglutaric aciduria 2
ClinVar Allele ID
29755
ClinVar RefSeq Alternation Syntax
NM_001290114.2:c.29G>A
ClinVar RefSeq Alternation Syntax
NM_001289910.1:c.263G>A
ClinVar RefSeq Alternation Syntax
NM_002168.4:c.419G>A
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2022-02-02
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000015831
ClinVar Disease
D-2-hydroxyglutaric aciduria 2
Observed Origin Sample
germline
Observed Origin Sample
de novo
Observed Origin Sample
unknown
Pubmed
24049096
Pubmed
20171147
Pubmed
23558173
Pubmed
20847235
Drugs