Annotation Detail

Information
Associated Genes
POLG POLGARF
Associated Variants
POLG p.Gln497His (p.Q497H) ( ENST00000268124.11, ENST00000636937.2, ENST00000442287.6 )
POLG p.Gln497His (p.Q497H) ( ENST00000268124.11, ENST00000442287.6, ENST00000636937.2 )
Associated Disease
Spinocerebellar ataxia with epilepsy
Source Database
ClinVar
Description
NM_002693.3(POLG):c.1491G>C (p.Gln497His) AND Spinocerebellar ataxia with epilepsy
ClinVar Allele ID
28549
ClinVar RefSeq Alternation Syntax
NM_001126131.2:c.1491G>C
ClinVar RefSeq Alternation Syntax
NM_002693.3:c.1491G>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2005-04-12
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014464
ClinVar Disease
Spinocerebellar ataxia with epilepsy
Observed Origin Sample
germline
Pubmed
15824347
Drugs