Annotation Detail

Information
Associated Genes
POLG POLGARF
Associated Variants
POLG p.Trp748Ser (p.W748S) ( ENST00000442287.6, ENST00000636937.2, ENST00000268124.11 )
POLG p.Trp748Ser (p.W748S) ( ENST00000268124.11, ENST00000442287.6, ENST00000636937.2 )
Associated Disease
Spinocerebellar ataxia with epilepsy
Source Database
ClinVar
Description
NM_002693.3(POLG):c.2243G>C (p.Trp748Ser) AND Spinocerebellar ataxia with epilepsy
ClinVar Allele ID
28546
ClinVar RefSeq Alternation Syntax
NM_001126131.2:c.2243G>C
ClinVar RefSeq Alternation Syntax
NM_002693.3:c.2243G>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2007-12-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014460
ClinVar Disease
Spinocerebellar ataxia with epilepsy
Observed Origin Sample
germline
Pubmed
17426723
Pubmed
15929042
Pubmed
16177225
Pubmed
17894835
Pubmed
15477547
Pubmed
11571332
Pubmed
16080118
Pubmed
15824347
Drugs