Annotation Detail

Information
Associated Genes
PRNP
Associated Variants
PRNP p.Gly131Val (p.G131V) ( ENST00000379440.9, ENST00000424424.2, ENST00000430350.2, ENST00000457586.2 )
PRNP p.Gly131Val (p.G131V) ( ENST00000379440.9, ENST00000424424.2, ENST00000430350.2, ENST00000457586.2 )
Associated Disease
Gerstmann-Straussler-Scheinker syndrome
Source Database
ClinVar
Description
NM_000311.5(PRNP):c.392G>T (p.Gly131Val) AND Gerstmann-Straussler-Scheinker syndrome
ClinVar Allele ID
28449
ClinVar RefSeq Alternation Syntax
NM_001271561.3:c.*81G>T
ClinVar RefSeq Alternation Syntax
NM_001080123.3:c.392G>T
ClinVar RefSeq Alternation Syntax
NM_000311.5:c.392G>T
ClinVar RefSeq Alternation Syntax
NM_001080122.3:c.392G>T
ClinVar RefSeq Alternation Syntax
NM_001080121.3:c.392G>T
ClinVar RefSeq Alternation Syntax
NM_183079.4:c.392G>T
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2023-03-21
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014351
ClinVar Disease
Gerstmann-Straussler-Scheinker syndrome
Observed Origin Sample
germline
Pubmed
11709001
Drugs