Annotation Detail

Information
Associated Genes
PRNP
Associated Variants
PRNP p.Val180Ile (p.V180I) ( ENST00000379440.9, ENST00000424424.2, ENST00000430350.2, ENST00000457586.2 )
PRNP p.Val180Ile (p.V180I) ( ENST00000457586.2, ENST00000430350.2, ENST00000379440.9, ENST00000424424.2 )
Associated Disease
Inherited Creutzfeldt-Jakob disease
Source Database
ClinVar
Description
NM_000311.5(PRNP):c.538G>A (p.Val180Ile) AND Inherited Creutzfeldt-Jakob disease
ClinVar Allele ID
28444
ClinVar RefSeq Alternation Syntax
NM_183079.4:c.538G>A
ClinVar RefSeq Alternation Syntax
NM_001080123.3:c.538G>A
ClinVar RefSeq Alternation Syntax
NM_001271561.3:c.*227G>A
ClinVar RefSeq Alternation Syntax
NM_000311.5:c.538G>A
ClinVar RefSeq Alternation Syntax
NM_001080122.3:c.538G>A
ClinVar RefSeq Alternation Syntax
NM_001080121.3:c.538G>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2016-03-18
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014344
ClinVar Disease
Inherited Creutzfeldt-Jakob disease
Observed Origin Sample
germline
Pubmed
8461023
Pubmed
26791950
Pubmed
14872044
Drugs