Annotation Detail

Information
Associated Genes
PRNP
Associated Variants
PRNP p.Pro105Leu (p.P105L) ( ENST00000379440.9, ENST00000424424.2, ENST00000430350.2, ENST00000457586.2 )
PRNP p.Pro105Leu (p.P105L) ( ENST00000457586.2, ENST00000379440.9, ENST00000430350.2, ENST00000424424.2 )
Associated Disease
Gerstmann-Straussler-Scheinker syndrome
Source Database
ClinVar
Description
NM_000311.5(PRNP):c.314C>T (p.Pro105Leu) AND Gerstmann-Straussler-Scheinker syndrome
ClinVar Allele ID
28443
ClinVar RefSeq Alternation Syntax
NM_000311.5:c.314C>T
ClinVar RefSeq Alternation Syntax
NM_001271561.3:c.*3C>T
ClinVar RefSeq Alternation Syntax
NM_001080122.3:c.314C>T
ClinVar RefSeq Alternation Syntax
NM_001080121.3:c.314C>T
ClinVar RefSeq Alternation Syntax
NM_183079.4:c.314C>T
ClinVar RefSeq Alternation Syntax
NM_001080123.3:c.314C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1993-12-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014343
ClinVar Disease
Gerstmann-Straussler-Scheinker syndrome
Observed Origin Sample
germline
Pubmed
7902972
Drugs