Annotation Detail

Information
Associated Genes
PRNP
Associated Variants
PRNP p.Ala117Val (p.A117V) ( ENST00000379440.9, ENST00000424424.2, ENST00000430350.2, ENST00000457586.2 )
PRNP p.Ala117Val (p.A117V) ( ENST00000379440.9, ENST00000424424.2, ENST00000430350.2, ENST00000457586.2 )
Associated Disease
Gerstmann-Straussler-Scheinker syndrome
Source Database
ClinVar
Description
NM_000311.5(PRNP):c.350C>T (p.Ala117Val) AND Gerstmann-Straussler-Scheinker syndrome
ClinVar Allele ID
28435
ClinVar RefSeq Alternation Syntax
NM_001271561.3:c.*39C>T
ClinVar RefSeq Alternation Syntax
NM_000311.5:c.350C>T
ClinVar RefSeq Alternation Syntax
NM_001080121.3:c.350C>T
ClinVar RefSeq Alternation Syntax
NM_001080122.3:c.350C>T
ClinVar RefSeq Alternation Syntax
NM_183079.4:c.350C>T
ClinVar RefSeq Alternation Syntax
NM_001080123.3:c.350C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1999-10-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014330
ClinVar Disease
Gerstmann-Straussler-Scheinker syndrome
Observed Origin Sample
germline
Pubmed
10506086
Pubmed
7501157
Pubmed
9452375
Pubmed
2783132
Drugs