Annotation Detail

Information
Associated Genes
INS INS-IGF2
Associated Variants
INS p.Arg89Leu (p.R89L), INS-IGF2 c.187+866G>T ( ENST00000512523.1, ENST00000381330.5, ENST00000397270.1, ENST00000397262.5, ENST00000250971.7 )
INS p.Arg89Leu (p.R89L), INS-IGF2 c.187+866G>T ( ENST00000250971.7, ENST00000381330.5, ENST00000397262.5, ENST00000512523.1, ENST00000397270.1 )
Associated Disease
Hyperproinsulinemia
Source Database
ClinVar
Description
NM_000207.3(INS):c.266G>T (p.Arg89Leu) AND Hyperproinsulinemia
ClinVar Allele ID
28421
ClinVar RefSeq Alternation Syntax
NM_001291897.2:c.266G>T
ClinVar RefSeq Alternation Syntax
NM_001185097.2:c.266G>T
ClinVar RefSeq Alternation Syntax
NM_001042376.3:c.187+866G>T
ClinVar RefSeq Alternation Syntax
NM_000207.3:c.266G>T
ClinVar RefSeq Alternation Syntax
NM_001185098.2:c.266G>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1992-06-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014313
ClinVar Disease
Hyperproinsulinemia
Observed Origin Sample
germline
Pubmed
1601997
Drugs