Annotation Detail

Information
Associated Genes
INS INS-IGF2
Associated Variants
INS p.Arg89His (p.R89H), INS-IGF2 c.187+866G>A ( ENST00000397270.1, ENST00000381330.5, ENST00000397262.5, ENST00000250971.7, ENST00000512523.1 )
INS p.Arg89His (p.R89H), INS-IGF2 c.187+866G>A ( ENST00000250971.7, ENST00000381330.5, ENST00000397262.5, ENST00000512523.1, ENST00000397270.1 )
Associated Disease
Hyperproinsulinemia
Source Database
ClinVar
Description
NM_000207.3(INS):c.266G>A (p.Arg89His) AND Hyperproinsulinemia
ClinVar Allele ID
28419
ClinVar RefSeq Alternation Syntax
NM_001185097.2:c.266G>A
ClinVar RefSeq Alternation Syntax
NM_000207.3:c.266G>A
ClinVar RefSeq Alternation Syntax
NM_001185098.2:c.266G>A
ClinVar RefSeq Alternation Syntax
NM_001291897.2:c.266G>A
ClinVar RefSeq Alternation Syntax
NM_001042376.3:c.187+866G>A
Clinical Significance Description
Conflicting interpretations of pathogenicity
Clinical Significance Last Update
2022-08-03
Clinical Significance Review Status
criteria provided, conflicting interpretations
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014310
ClinVar Disease
Hyperproinsulinemia
Observed Origin Sample
germline
Observed Origin Sample
unknown
Pubmed
8636380
Pubmed
7242673
Pubmed
4019786
Pubmed
2196279
Pubmed
6368587
Pubmed
9667398
Drugs