Annotation Detail

Information
Associated Genes
INS INS-IGF2
Associated Variants
INS p.Phe48Ser (p.F48S), INS-IGF2 p.Phe48Ser (p.F48S) ( ENST00000397270.1, ENST00000381330.5, ENST00000397262.5, ENST00000250971.7, ENST00000512523.1 )
INS p.Phe48Ser (p.F48S), INS-IGF2 p.Phe48Ser (p.F48S) ( ENST00000250971.7, ENST00000381330.5, ENST00000397262.5, ENST00000512523.1, ENST00000397270.1 )
Associated Disease
Hyperproinsulinemia
Source Database
ClinVar
Description
NM_000207.3(INS):c.143T>C (p.Phe48Ser) AND Hyperproinsulinemia
ClinVar Allele ID
28417
ClinVar RefSeq Alternation Syntax
NM_001042376.3:c.143T>C
ClinVar RefSeq Alternation Syntax
NM_001185097.2:c.143T>C
ClinVar RefSeq Alternation Syntax
NM_001291897.2:c.143T>C
ClinVar RefSeq Alternation Syntax
NM_000207.3:c.143T>C
ClinVar RefSeq Alternation Syntax
NM_001185098.2:c.143T>C
ClinVar RefSeq Alternation Syntax
NR_003512.4:n.202T>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1993-01-15
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014307
ClinVar Disease
Hyperproinsulinemia
Observed Origin Sample
germline
Pubmed
6339950
Pubmed
8421693
Pubmed
6312455
Pubmed
6371526
Drugs