Annotation Detail

Information
Associated Genes
FGFR2
Associated Variants
FGFR2 c.1087+1305C>G ( ENST00000478859.5, ENST00000682550.1, ENST00000613048.4, ENST00000638709.2, ENST00000369056.5, ENST00000360144.7, ENST00000351936.11, ENST00000369060.8, ENST00000358487.10, ENST00000369059.5, ENST00000683211.1, ENST00000357555.9, ENST00000346997.6, ENST00000369061.8, ENST00000682772.1, ENST00000457416.7, ENST00000684153.1, ENST00000356226.8 )
FGFR2 c.1087+1305C>G ( ENST00000346997.6, ENST00000351936.11, ENST00000356226.8, ENST00000357555.9, ENST00000358487.10, ENST00000360144.7, ENST00000369056.5, ENST00000369059.5, ENST00000369060.8, ENST00000369061.8, ENST00000457416.7, ENST00000478859.5, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1, ENST00000684153.1 )
Associated Disease
Crouzon syndrome
Source Database
ClinVar
Description
NM_000141.5(FGFR2):c.1026C>G (p.Cys342Trp) AND Crouzon syndrome
ClinVar Allele ID
28314
ClinVar RefSeq Alternation Syntax
NM_001320654.2:c.342C>G
ClinVar RefSeq Alternation Syntax
NM_001144913.1:c.1087+1305C>G
ClinVar RefSeq Alternation Syntax
NM_001144917.2:c.939+2602C>G
ClinVar RefSeq Alternation Syntax
NM_001144916.2:c.681C>G
ClinVar RefSeq Alternation Syntax
NM_022970.4:c.1087+1305C>G
ClinVar RefSeq Alternation Syntax
NR_073009.2:n.1462C>G
ClinVar RefSeq Alternation Syntax
NM_001144918.2:c.681C>G
ClinVar RefSeq Alternation Syntax
NM_001144915.2:c.759C>G
ClinVar RefSeq Alternation Syntax
NM_023029.2:c.759C>G
ClinVar RefSeq Alternation Syntax
NM_001144914.1:c.749-2058C>G
ClinVar RefSeq Alternation Syntax
NM_000141.5:c.1026C>G
ClinVar RefSeq Alternation Syntax
NM_001320658.2:c.1026C>G
ClinVar RefSeq Alternation Syntax
NM_001144919.2:c.820+1305C>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1997-02-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000014195
ClinVar Disease
Crouzon syndrome
Observed Origin Sample
germline
Pubmed
2172978
Pubmed
7607643
Pubmed
1697263
Pubmed
9048930
Pubmed
8522336
Drugs