Annotation Detail

Information
Associated Genes
ABL1
Associated Variants
ABL1 p.Tyr272His (p.Y272H) ( ENST00000318560.6, ENST00000372348.9 )
ABL1 p.Tyr272His (p.Y272H) ( ENST00000318560.6, ENST00000372348.9 )
Associated Disease
Leukemia, Philadelphia chromosome-positive, resistant to imatinib
Source Database
ClinVar
Description
NM_005157.6(ABL1):c.757T>C (p.Tyr253His) AND Leukemia, Philadelphia chromosome-positive, resistant to imatinib
ClinVar Allele ID
27666
ClinVar RefSeq Alternation Syntax
NM_005157.6:c.757T>C
ClinVar RefSeq Alternation Syntax
NM_007313.3:c.814T>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2002-02-09
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000013462
ClinVar Disease
Leukemia, Philadelphia chromosome-positive, resistant to imatinib
Observed Origin Sample
germline
Pubmed
11853795
Drugs