Annotation Detail

Information
Associated Genes
KRAS
Associated Variants
KRAS p.Thr58Ile (p.T58I) ( ENST00000256078.10, ENST00000311936.8, ENST00000557334.6, ENST00000685328.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 )
KRAS p.Thr58Ile (p.T58I) ( ENST00000311936.8, ENST00000557334.6, ENST00000685328.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1, ENST00000256078.10 )
Associated Disease
Noonan syndrome 3
Source Database
ClinVar
Description
NM_004985.5(KRAS):c.173C>T (p.Thr58Ile) AND Noonan syndrome 3
ClinVar Allele ID
27627
ClinVar RefSeq Alternation Syntax
NM_001369787.1:c.173C>T
ClinVar RefSeq Alternation Syntax
NM_001369786.1:c.173C>T
ClinVar RefSeq Alternation Syntax
NM_033360.4:c.173C>T
ClinVar RefSeq Alternation Syntax
NM_004985.5:c.173C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-04-14
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000013419
ClinVar Disease
Noonan syndrome 3
Observed Origin Sample
germline
Pubmed
19396835
Pubmed
16474405
Drugs