Annotation Detail

Information
Associated Genes
TPM1
Associated Variants
TPM1 p.Asp217Asn (p.D217N) ( ENST00000559556.5, ENST00000559397.6, ENST00000560970.6, ENST00000561266.6, ENST00000357980.9, ENST00000358278.7, ENST00000317516.12, ENST00000560615.6, ENST00000334895.10, ENST00000560959.5, ENST00000403994.9, ENST00000558910.3, ENST00000559281.6, ENST00000288398.10, ENST00000404484.9, ENST00000267996.11, ENST00000651704.1, ENST00000714013.1, ENST00000651577.1, ENST00000714014.1, ENST00000714017.1 )
TPM1 p.Asp217Asn (p.D217N) ( ENST00000267996.11, ENST00000288398.10, ENST00000317516.12, ENST00000334895.10, ENST00000357980.9, ENST00000358278.7, ENST00000403994.9, ENST00000404484.9, ENST00000558910.3, ENST00000559281.6, ENST00000559397.6, ENST00000559556.5, ENST00000560615.6, ENST00000560959.5, ENST00000560970.6, ENST00000561266.6, ENST00000651577.1, ENST00000651704.1, ENST00000714013.1, ENST00000714014.1, ENST00000714017.1 )
Associated Disease
hypertrophic cardiomyopathy 3
Source Database
ClinVar
Description
NM_001018005.2(TPM1):c.523G>A (p.Asp175Asn) AND Hypertrophic cardiomyopathy 3
ClinVar Allele ID
27495
ClinVar RefSeq Alternation Syntax
NM_001365778.1:c.649G>A
ClinVar RefSeq Alternation Syntax
NM_001018008.2:c.415G>A
ClinVar RefSeq Alternation Syntax
NM_001365776.1:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_000366.6:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001018006.2:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001365779.1:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001365781.2:c.415G>A
ClinVar RefSeq Alternation Syntax
NM_001018020.2:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001301244.2:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001365777.1:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001330351.2:c.415G>A
ClinVar RefSeq Alternation Syntax
NM_001018005.2:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001330346.2:c.415G>A
ClinVar RefSeq Alternation Syntax
NM_001018007.2:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001301289.2:c.415G>A
ClinVar RefSeq Alternation Syntax
NM_001330344.2:c.415G>A
ClinVar RefSeq Alternation Syntax
NM_001018004.2:c.523G>A
ClinVar RefSeq Alternation Syntax
NM_001365782.1:c.415G>A
ClinVar RefSeq Alternation Syntax
NM_001365780.1:c.415G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-05-24
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000013272
ClinVar Disease
Hypertrophic cardiomyopathy 3
Observed Origin Sample
germline
Observed Origin Sample
unknown
Pubmed
7729014
Pubmed
8205619
Drugs