Annotation Detail

Information
Associated Genes
UGT1A UGT1A10 UGT1A8 UGT1A7 UGT1A6 UGT1A5 UGT1A9 UGT1A4 UGT1A1 UGT1A3
Associated Variants
UGT1A6 p.Tyr485Asp (p.Y485D), UGT1A5 p.Tyr487Asp (p.Y487D), UGT1A9 p.Tyr483Asp (p.Y483D), UGT1A7 p.Tyr483Asp (p.Y483D), UGT1A4 p.Tyr487Asp (p.Y487D), UGT1A8 p.Tyr483Asp (p.Y483D), UGT1A10 p.Tyr483Asp (p.Y483D), UGT1A3 p.Tyr487Asp (p.Y487D), UGT1A1 p.Tyr486Asp (p.Y486D) ( ENST00000482026.6, ENST00000305208.10, ENST00000373424.5, ENST00000373414.4, ENST00000344644.10, ENST00000373450.5, ENST00000305139.11, ENST00000373426.4, ENST00000354728.5, ENST00000373409.8 )
UGT1A6 p.Tyr485Asp (p.Y485D), UGT1A5 p.Tyr487Asp (p.Y487D), UGT1A9 p.Tyr483Asp (p.Y483D), UGT1A7 p.Tyr483Asp (p.Y483D), UGT1A4 p.Tyr487Asp (p.Y487D), UGT1A8 p.Tyr483Asp (p.Y483D), UGT1A10 p.Tyr483Asp (p.Y483D), UGT1A3 p.Tyr487Asp (p.Y487D), UGT1A1 p.Tyr486Asp (p.Y486D) ( ENST00000344644.10, ENST00000373450.5, ENST00000373426.4, ENST00000305139.11, ENST00000373424.5, ENST00000373414.4, ENST00000354728.5, ENST00000373409.8, ENST00000305208.10, ENST00000482026.6 )
Associated Disease
Lucey-Driscoll syndrome
Source Database
ClinVar
Description
NM_000463.3(UGT1A1):c.1456T>G (p.Tyr486Asp) AND Lucey-Driscoll syndrome
ClinVar Allele ID
27320
ClinVar RefSeq Alternation Syntax
NM_007120.3:c.1459T>G
ClinVar RefSeq Alternation Syntax
NM_019076.5:c.1447T>G
ClinVar RefSeq Alternation Syntax
NM_001072.4:c.1453T>G
ClinVar RefSeq Alternation Syntax
NM_019075.4:c.1447T>G
ClinVar RefSeq Alternation Syntax
NM_019077.3:c.1447T>G
ClinVar RefSeq Alternation Syntax
NM_019078.2:c.1459T>G
ClinVar RefSeq Alternation Syntax
NM_019093.4:c.1459T>G
ClinVar RefSeq Alternation Syntax
NM_000463.3:c.1456T>G
ClinVar RefSeq Alternation Syntax
NM_205862.3:c.652T>G
ClinVar RefSeq Alternation Syntax
NM_021027.3:c.1447T>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2007-12-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000013073
ClinVar Disease
Lucey-Driscoll syndrome
Observed Origin Sample
germline
Pubmed
18004206
Pubmed
11061796
Drugs