Annotation Detail

Information
Associated Genes
CYP21A2 LOC106780800 LOC110631417
Associated Variants
CYP21A2 c.-4C>T ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Pro106Leu (p.P106L) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Pro454Ser (p.P454S) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 c.-4C>T ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Pro106Leu (p.P106L) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Pro454Ser (p.P454S) ( ENST00000435122.3, ENST00000644719.2 )
Associated Disease
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Source Database
ClinVar
Description
NM_000500.9(CYP21A2):c.[-4C>T;1360C>T317C>T] AND Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
ClinVar Allele ID
27197
ClinVar Allele ID
27198
ClinVar Allele ID
252220
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.227C>T
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.-338C>T
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.-428C>T
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.317C>T
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.-4C>T
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.955C>T
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.1270C>T
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.955C>T
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.-4C>T
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.1360C>T
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.-89C>T
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.-89C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
1997-01-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000012942
ClinVar Disease
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Observed Origin Sample
germline
Pubmed
8989258
Pubmed
1406699
Pubmed
8081391
Pubmed
1496017
Drugs