Annotation Detail

Information
Associated Genes
CYP21A2 TNXB LOC106780800
Associated Variants
CYP21A2 p.Arg357Trp (p.R357W) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Arg357Trp (p.R357W) ( ENST00000435122.3, ENST00000644719.2 )
Associated Disease
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Source Database
ClinVar
Description
NM_000500.9(CYP21A2):c.1069C>T (p.Arg357Trp) AND Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
ClinVar Allele ID
27191
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.664C>T
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.979C>T
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.664C>T
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.1069C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-12-21
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000012937
ClinVar Disease
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Observed Origin Sample
germline
Observed Origin Sample
unknown
Pubmed
2303461
Pubmed
9215318
Pubmed
1496017
Drugs