Annotation Detail

Information
Associated Genes
CYP21A2 LOC106780800
Associated Variants
CYP21A2 p.Ile173Asn (p.I173N) ( ENST00000435122.3, ENST00000644719.2 )
CYP21A2 p.Ile173Asn (p.I173N) ( ENST00000435122.3, ENST00000644719.2 )
Associated Disease
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Source Database
ClinVar
Description
NM_000500.9(CYP21A2):c.518T>A (p.Ile173Asn) AND Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
ClinVar Allele ID
27189
ClinVar RefSeq Alternation Syntax
NM_001128590.4:c.428T>A
ClinVar RefSeq Alternation Syntax
NM_001368143.2:c.113T>A
ClinVar RefSeq Alternation Syntax
NM_001368144.2:c.113T>A
ClinVar RefSeq Alternation Syntax
NM_000500.9:c.518T>A
Clinical Significance Description
Conflicting interpretations of pathogenicity
Clinical Significance Last Update
2024-04-04
Clinical Significance Review Status
criteria provided, conflicting interpretations
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000012933
ClinVar Disease
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Observed Origin Sample
germline
Observed Origin Sample
inherited
Observed Origin Sample
unknown
Pubmed
2303461
Pubmed
8175971
Pubmed
1644925
Pubmed
1937474
Pubmed
8081391
Pubmed
9215318
Pubmed
3257825
Pubmed
1496017
Drugs