Annotation Detail

Information
Associated Genes
SCN5A
Associated Variants
SCN5A p.His558Arg (p.H558R) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Thr512Ile (p.T512I) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.His558Arg (p.H558R) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
SCN5A p.Thr512Ile (p.T512I) ( ENST00000333535.9, ENST00000413689.6, ENST00000414099.6, ENST00000423572.7, ENST00000449557.6, ENST00000450102.6, ENST00000455624.6 )
Associated Disease
Progressive familial heart block, type 1A
Source Database
ClinVar
Description
NM_198056.2(SCN5A):c.[1535C>T;1673A>G] AND Progressive familial heart block, type 1A
ClinVar Allele ID
38447
ClinVar Allele ID
24437
ClinVar RefSeq Alternation Syntax
NM_001160160.2:c.1673A>G
ClinVar RefSeq Alternation Syntax
NM_001099405.2:c.1535C>T
ClinVar RefSeq Alternation Syntax
NM_198056.3:c.1535C>T
ClinVar RefSeq Alternation Syntax
NM_001160161.2:c.1673A>G
ClinVar RefSeq Alternation Syntax
NM_001160161.2:c.1535C>T
ClinVar RefSeq Alternation Syntax
NM_001354701.2:c.1535C>T
ClinVar RefSeq Alternation Syntax
NM_000335.5:c.1535C>T
ClinVar RefSeq Alternation Syntax
NM_001099404.2:c.1535C>T
ClinVar RefSeq Alternation Syntax
NM_001160160.2:c.1535C>T
ClinVar RefSeq Alternation Syntax
NM_001099404.2:c.1673A>G
ClinVar RefSeq Alternation Syntax
NM_001354701.2:c.1673A>G
ClinVar RefSeq Alternation Syntax
NM_000335.5:c.1673A>G
ClinVar RefSeq Alternation Syntax
NM_198056.3:c.1673A>G
ClinVar RefSeq Alternation Syntax
NM_001099405.2:c.1673A>G
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2008-04-15
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000010000
ClinVar Disease
Progressive familial heart block, type 1A
Observed Origin Sample
germline
Pubmed
11997281
Pubmed
12569159
Pubmed
18378609
Drugs