Annotation Detail

Information
Associated Genes
PTCH1 LOC100507346
Associated Variants
PTCH1 p.Thr728Met (p.T728M) ( ENST00000429896.6, ENST00000331920.11, ENST00000430669.6, ENST00000437951.6, ENST00000692981.1, ENST00000711046.1 )
PTCH1 p.Thr728Met (p.T728M) ( ENST00000331920.11, ENST00000429896.6, ENST00000430669.6, ENST00000437951.6, ENST00000692981.1, ENST00000711046.1 )
Associated Disease
holoprosencephaly 7
Source Database
ClinVar
Description
NM_000264.5(PTCH1):c.2183C>T (p.Thr728Met) AND Holoprosencephaly 7
ClinVar Allele ID
23261
ClinVar RefSeq Alternation Syntax
NM_001083606.3:c.1730C>T
ClinVar RefSeq Alternation Syntax
NM_001083605.3:c.1730C>T
ClinVar RefSeq Alternation Syntax
NM_001083607.3:c.1730C>T
ClinVar RefSeq Alternation Syntax
NR_038982.1:n.756G>A
ClinVar RefSeq Alternation Syntax
NM_001083604.3:c.1730C>T
ClinVar RefSeq Alternation Syntax
NR_149061.2:n.3088C>T
ClinVar RefSeq Alternation Syntax
NM_000264.5:c.2183C>T
ClinVar RefSeq Alternation Syntax
NM_001354918.2:c.2027C>T
ClinVar RefSeq Alternation Syntax
NM_001083602.3:c.1985C>T
ClinVar RefSeq Alternation Syntax
NM_001083603.3:c.2180C>T
Clinical Significance Description
Likely benign
Clinical Significance Last Update
2017-04-27
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000008705
ClinVar Disease
Holoprosencephaly 7
Observed Origin Sample
germline
Pubmed
17096318
Pubmed
11941477
Drugs